PTEN negatively regulates the cell lineage progression from NG 2 + glial 2 progenitor to oligodendrocyte via mTOR - independent signaling
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چکیده
9 Shriners Hospitals Pediatric Research Center, and Department of Anatomy and Cell 10 Biology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA. 11 Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Japan. 12 13 Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg 14 University of Mainz, 55131 Mainz, Germany. 15
منابع مشابه
PTEN negatively regulates the cell lineage progression from NG2+ glial progenitor to oligodendrocyte via mTOR-independent signaling
Oligodendrocytes (OLs), the myelin-forming CNS glia, are highly vulnerable to cellular stresses, and a severe myelin loss underlies numerous CNS disorders. Expedited OL regeneration may prevent further axonal damage and facilitate functional CNS repair. Although adult OL progenitors (OPCs) are the primary players for OL regeneration, targetable OPC-specific intracellular signaling mechanisms fo...
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تاریخ انتشار 2018